Comparative antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing mouthrinse and a cetylpyridinium chloride-containing mouthrinse:A 6-month randomized clinical trial (CortelIi, et al. 2012)
This 6-month, examiner-blind, single-center, randomized, parallel group clinical trial compared the antiplaque and antigingivitis effects of an essential oil-containing mouthrinse with zinc chloride and sodium fluoride (EO) to a 0.05% cetylpyridinium chloride-containing mouthrinse (CPC) also with fluoride.
Methods: Four hundred and eight gingivitis subjects were monitored for the primary outcomes of Modified Gingival Index (MGI) and Plaque Index (Pl) at baseline and 3 and 6 months. Subjects were randomly assigned to 6-month twice a day unsupervised use of EO,CPC,or negative control rinse in conjunction with normal brushing and flossing.
Results: EO was always better than CPC at 3 and 6 months considering all parameters. All benefits allowed by EO increased from 3 to 6 months. CPC was better than the negative control at 3 and 6 months with respect to whole mouth plaque, and the proportion of more severe sites (baseline scores 3) in Pl and MGI. At 6 months, CPC did not differ from negative control in relation to whole mouth MGI reduction, proximal MGI reduction, and percentages of sites improved over baseline in Pl and MGI.
Conclusion: This new EO mouthrinse provided superior clinical benefits to CPC and demonstrated increasing plaque and gingivitis reductions over 6 months. Our findings support the regular long-term use of the EO mouthrinse and selection over a 0.05% CPC rinse for better efficacy.
Cortelli SC, Cortelli JR, Wu MM, et al. Comparative antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing mouthrinse and a cetylpyridinium chloride-con taining mouthrinse: A 6·month randomized clinical trial. QI 2012; 43:e82·e94.
COMPARATIVE ANTIPLAQUE AND ANTIGINGIVITIS EFFECTIVENESS
OF A CHLORHEXIDINE AND AN ESSENTIAL OIL MOUTHRINSE
This clinical study demonstrated that the essential oil mouthrinse and these chlorhexidine mouthrinse had comparable antiplaque and antigingivitis activity.